just-dna-lite
Medical Disclaimer / RUO
AnnotationModule CatalogFAQ
Add Sample

or import from Zenodo

Try a public genome
Anton KulagaCC-Zero
Livia ZahariaCC-BY-4.0
Voluntarily shared under open licenses for research use.
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Upload a VCF file or import from Zenodo to get started
Start in the left panel — add or select a sample to begin

Just-DNA-Lite

Explore your genome on your own computer. Nothing is sent to a server.

Medical disclaimer (research use only)

This tool is for research, educational, and self-exploration purposes only. It is not a medical device and provides no medical advice. The genetic modules and polygenic risk scores here are not clinically validated. Do not use this tool for diagnostic or medical decisions. Interesting findings should be re-tested with a clinically validated method in a certified lab.

You need a VCF: the file your sequencing provider already produced. It is a table of places your DNA differs from a reference genome. The diagram below shows how that file is made, and what you do with it here.

You are here download this file from your sequencing provider Full-genome sequencing — already done by your sequencing provider DNA sample what you sent in saliva / blood Sequencing machine reads your DNA FASTQ Alignment reads mapped to genome BAM / CRAM Variant calling your genetic variants VCF (.vcf / .vcf.gz) Annotation & PRS Just-DNA-Lite — this app reports & scores
Inside Just-DNA-Lite — your steps
The green buttons are clickable and point to the matching controls; grey boxes are a map of what happens where.
and / or new modules extend the list research papers AI agent 1 Add a sample ← in the left panel Upload your VCF or Try a public genome 2 Annotation modules pick modules (longevity, cardio …) and run the annotation pipeline 2 PRS — risk scores compute polygenic risk scores directly, no modules needed 3 Explore results reports, tables, and scores appear in this panel + Module Manager create & install new modules, its own tab in the top menu AI Ask AI about results take your reports to any AI assistant you trust
Reference genome. The standard map of human DNA that labs write positions against. Most current files use GRCh38; choose that unless your provider used GRCh37/hg19.
This tool annotates a VCF. It does not sequence DNA or call variants. The file is only as complete as the lab that made it.
23andMe and Ancestry are not sequencing. Those services read a few hundred thousand pre-selected spots on a chip, not the whole genome. Support for those files is planned; for now the tool is built for whole-genome and whole-exome VCFs.

Core Philosophy

Your data, your call
Runs entirely on your machine. Nothing leaves your computer.
Unfiltered access
We show the full research view, not a pre-filtered clinical summary.
Speed & Iteration
We optimize for rapid exploration and fast module creation, not clinical-style validation cycles.
Scientific realism
Modules, PRS, and especially AI-generated content can be wrong, incomplete, or clinically irrelevant.